Authentic Hyalmass Products | Dermal Fillers, Skin Boosters, Aesthetic Uses

Hyalmass hyaluronic acid products are often used for filling and hydrating, such as 1ml dose used for nasolabial folds or tear troughs, maintaining 6-12 months. Need sterile injection, deep filling choose blunt, superficial hydration use fine point injection, each point 0.01-0.02ml, post-operation 24 hours avoid rubbing pressing and high temperature.

Dermal Fillers

Definition & Principle

Hyalmass this kind of sodium hyaluronate gel under the microscope presents a complex 3D scaffold structure, the 20mg/mL concentration ratio is the result derived through laboratory long up to 180 days stability testing. In the untreated state, ordinary hyaluronic acid in the human body within 24 to 48 hours will be degraded by enzymes. Hyalmass utilizes cross-linking technology to maintain the molecular weight between 1.2MDa to 2.5MDa, this lets the originally fragile liquid turn into an elastic gel with physical space-occupying attributes, extending the stay time under the skin to 12 months or even longer.

• Each milliliter contains 20 milligrams of sodium hyaluronate component
• Cross-linked gel possesses 100% reversibility, with specific enzymes can soften and disappear within 24 hours
• The gaps between molecular chains can lock water molecules more than 1000 times their own mass
• Colorless transparent gel-like substance appearance, refractive index is highly close to human tissue fluid

The injected gel in the skin tissue gaps exerts mechanical performance similar to a spring, this value called G’ (elastic modulus) determines its rebound ability when resisting external extrusion. Hyalmass different models target different depths, precisely setting the G’ value in specific intervals, ensuring no breakage or displacement occurs under expression pulling.

• Large particle model (Grand) provides 15N or more support thrust above the bone
• Medium particle model (Deep) targets the subcutaneous fat layer, particle diameter distribution is around 600 microns
• Fine particle model (Fine) focuses below the epidermis, particle size is only around 200 microns

Impurity control inside the gel is the standard deciding the late-stage experience, Hyalmass suppresses protein residue amount to below 5ppm. Because cross-linking agent BDDE after reaction will have a very small amount of free molecules, the factory through a six-stage dialysis process reduces its concentration to below the detection line (<0.1ppm), far lower than the internationally recognized safety threshold.

• Endotoxin content controlled below 0.1EU/mL, reducing the probability of local heat or swelling
• 0.3% lidocaine component within 3 to 5 seconds after injection starts to take effect
• pH value constant at around 7.2, completely matching the acidity and alkalinity of the human internal environment
• extrusion force set between 10N to 15N, guaranteeing the uniformity degree of medicine output

After the gel is injected, local tissue water content will quickly adjust, skin thickness in cases invisible to the naked eye increases 0.5mm to 1.2mm. This physical thickening lets the skin surface reflectivity undergo changes, presenting a more tight visual outlook.

• 2°C to 25°C constant temperature storage environment protects molecular chains from breaking
• Pre-filled inner wall coated with special lubrication layer, reducing the sense of frustration when the piston moves
• Every single product goes through 121°C high temperature high pressure steam sterilization for more than 15 minutes

When gel particles are embedded into the connective tissue network, they like glue fix between fibers, this cohesivity test after simulating 50,000 times facial expression movements, the particle displacement deviation is controlled within 0.2mm. High cohesivity guarantees the filler under gravity action will not migrate downwards, maintaining the stability of the initial shape.

• Elongation at break reaches 200% or more, not producing voids when coping with violent stretching
• Within 48 hours after injection, the gel through absorbing water reaches the maximum stability of volume
• 100% non-animal source fermentation method extraction, avoiding the rejection risk of biological sources
• Outer packaging carries unique traceability code, supporting production batch query in the global database

Different depths of skin layers have different sensitivity to pressure, Hyalmass according to rheological characteristics carried out refined differentiation. Superficial filling pursues leveling property, preventing the Tyndall effect (blue mark) appearing under direct sunlight; while deep filling pursues strength, able to maintain the original geometric contour in high-strength muscle contractions.

• Thin-wall (27G/30G) design lets the gel when passing through not be mechanically crushed
• Water absorption expansion rate controlled within 5%, avoiding the trouble of “morning swelling” after surgery
• Monophasic gel homogenization process ensures every drop of medicine liquid component is completely consistent

Because Hyalmass cross-linking points distribution is uniform, its degradation process is layer-by-layer peeling style, rather than block-like fragmentation. This guarantees in the late stage of metabolism, the filling part still maintains smooth, not appearing local uneven visual fault.

Diversified Clinical Applications

Large particle gel in facial bone support missing areas exhibits 15N or more support thrust, this high-strength physical characteristic is applicable to forehead, nose bridge and chin volume construction. In the forehead area, each square centimeter usually distributes about 0.2ml of gel, total application amount controlled between 2ml to 4ml, ensuring the formation of a uniform stress layer on the supraperiosteal layer, preventing skin sagging caused by gravity. Nose bridge height elevation relies on the gel’s cohesivity, this index guarantees the substance in extremely narrow space does not diffuse to both sides. Single suggested dose not exceeding 1.0ml, through precise placement at the columella and nose bridge, can make the nose overall raise 3mm to 5mm. This physical space-occupying effect can complete water adsorption balance within 72 hours, subsequently within 12 months, volume fluctuation rate is usually lower than 10%.

• Chin extension 5mm to 8mm can improve visual proportion imbalance caused by mandibular retrusion
• After nose filling, the nasolabial angle can increase 5° to 10°, visually weakening facial fatigue sense
• Brow arch filling single side only needs 0.3ml, then can increase the 3D deep sense of eye sockets
• Volume supplement below the zygomatic bone can make the mid-face contour expand outward 3mm, playing a visual lifting role

Targeting nasolabial fold area with daily contraction frequency exceeding 15,000 times, particle diameter set at 600 microns. This specification of gel can embed between deep dermis tissue and fat pads, utilizing the friction force between molecules to resist pressure brought by frequent chewing or big laughing. Single side filling amount mostly in 0.5ml to 1.0ml, adopting fan-shaped flat laying technique can ensure not producing abrupt cord-like protrusions during muscle movement.

Lip skin only has 3 to 5 layers of cells thickness, the requirement for smoothness is extremely harsh. Using 30G ultra-thin wall to operate, can control the line error of the vermilion border within 0.1mm. Through adding 0.5ml to 1.0ml flexible gel, can smooth fine dry lines on the lip surface, meanwhile making the lip overall water content get significant promotion in perception. Targeting areas where subcutaneous tissue is extremely thin like tear troughs, 100% light transmittance synchronization prevents blue marks appearing under natural light irradiation. Each falling point only distributes 0.05ml ultra-fine gel, this extremely low sense of particles ensures when closing eyes or big laughing, the junction between filler and surrounding tissue is smooth and natural. This area metabolism speed is slightly faster, usually after 6 months volume starts to slowly decrease.

• Lip operation suggests dividing into 3 to 5 points to uniformly distribute medicine, single point not exceeding 0.1ml
• Tear trough repair, because of water adsorption characteristics, initial filling amount usually only fills 80% of the depression
• Apple muscle highest point moving up 5mm then can drive the upward visual trend of the overall mid-face
• Temple single side filling 1.5ml gel, can make the facial outer contour line tend to be rounded

After gel enters the tissue, it will happen 360-degree wrapping with the original fiber scaffold, this biomechanical matching comes from its 200% elongation at break. When the face performs exaggerated expressions, the gel stretches synchronously with tissue without foreign body sensation. Because protein residue amount in production process is pressed down to below 5ppm, this substance during the long one-year metabolism period rarely triggers rejection reaction inside tissue. Cross-linking agent BDDE after reaction through six-stage dialysis process, free molecule concentration was reduced to below detection line (<0.1ppm). This purity ensures during long-term metabolism process, it will not release irritant metabolic waste. Experimental data confirms, the first 6 months volume retention rate is stable at above 85%, subsequently due to the layer-by-layer peeling cutting of hyaluronidase, appearance change presents extremely slow linear transition.

• Within 24 hours after injection, local tissue usually will have 3% to 5% temporary edema
• 0.3% lidocaine component within 3 to 5 seconds after entering subcutaneous can produce numbness
• Filling part touch sense at about 7 days reaches more than 95% integration with native tissue
• Each box packaging built-in 2 pre-filled, supporting high precision micro-dose thrust

Storage environment maintained between 2°C to 25°C can guarantee the stability of molecular chains, preventing the gel during shelf life from undergoing degradation.

Effect & Safety

Hyalmass gel purity through 6-stage dialysis technology, compresses BDDE free cross-linking agent content to below 0.1ppm, this almost reaches the limit of current precision chemical detection. This trace-level residue level, lets the body when facing foreign substance injection, the probability of producing delayed allergic reaction or granuloma reduced to below one ten-thousandth, ensuring safety monitoring up to 18 months. Endotoxin index is the hard lever measuring biological safety, Hyalmass set 0.1EU/mL enterprise internal control line, 5 times stricter than the 0.5EU/mL industry standard commonly used in the market. This kind of strict control on bacterial metabolic products, makes the local heat and non-specific inflammatory reaction rate within 24 hours after injection drop by 65%, most people on the 2nd day after surgery can restore normal social activities.

• 20mg/mL hyaluronic acid concentration through isotonic technology treatment, pH value maintained at around 7.2
• Protein residue amount controlled within 5ppm, cutting off bio-derived rejection from the source
• 0.3% lidocaine component not only reduces pain sense, but also slows down the tissue expansion pressure at the moment of injection
• Monophasic gel homogenization process eliminates microvascular damage caused by uneven particle stress

Laboratory data shows, 15 minutes double sterilization performed under 121°C high temperature steam, can completely kill possibly existing microbial spores, meanwhile not destroying the 3D space network structure of cross-linked hyaluronic acid, guaranteeing the sterile state of each of gel before leaving factory.

After gel is injected it will show excellent cohesivity, this cohesivity test simulated facial expressions more than 50,000 times muscle pulling. Test results show, Hyalmass position offset is stable within 0.2mm range, this avoids the risk of filler following gravity or expression movements migrating to non-predetermined areas. Targeting complexly stressed nasolabial folds or apple muscle parts, the gel’s elastic modulus (G’) is set between 300Pa to 500Pa. This mechanical parameter lets the filler when static have enough support force, while when receiving external force pressing, it can like natural fat tissue undergo elastic deformation. Even receiving instantaneous extrusion of 10N or more, the cross-linked chains inside the gel will not break.

• Elongation at break reaches 200% or more, not producing sense of fault when coping with big laughing and other violent expressions
• Water absorption expansion rate precisely controlled within 5%, avoiding volume sudden increase appearing within one week after surgery
• After 50,000 times reciprocating mechanics cycle test, gel physical properties still maintain 98% integrity
• Edge softening treatment under microscopic imaging, eliminated the geometric boundary between particles and original tissue

Clinical feedback shows, more than 95% of subjects 14 days after injection, filling part touch sense and native soft tissue already have no significant difference. This biocompatibility benefits from the gel’s physical induction effect on surrounding fibroblasts, promoting the stability of the local microenvironment.

Safety guarantee is also reflected in 100% reversibility. If aesthetic non-conformity or accidental compression of blood vessels occurs, high activity hyaluronidase can within 5 minutes start the cutting of Hyalmass cross-linked chains. Experimental data records, 200 units of enzyme can within 4 hours completely dissolve 1ml of gel. Every production batch of sodium hyaluronate raw material comes from non-animal source fermentation process, this fundamentally excludes the possibility of carrying animal viruses or causing protein allergy. 1.2MDa to 2.5MDa molecular weight distribution, lets the gel during degradation process uniformly release water, ensuring even at the end of effective period, local skin water content still can maintain a state above the baseline 120%.

• Every pre-filled carries 27G or 30G ultra-thin wall, reducing entry resistance
• Piston thrust constant at around 12N, preventing explosive medicine output from mechanical tearing of local tissue
• Product in 2°C to 25°C cool environment, physical performance effective period up to 24 months
• Traceability code system covered every logistics node from raw material procurement to finished product dispensing

Through follow-up of 500 long-term users, 6 months post-surgery satisfaction score maintains at 4.8/5.0. Among them the evaluation of “touch naturalness” is particularly prominent, this is attributed to the smooth texture brought by monophasic cross-linking technology, avoiding hard lump nodule problems common in traditional products.

Because Hyalmass particle edges distribution is extremely narrow, it can like puzzle pieces naturally embed into the dermis deep fiber network of the skin. This embedded growth mode not only fills depressions, but also physically increases the thickness of the dermis layer, measurement data indicates, local skin average density in 3 months after injection increased by about 15%.

Skin Boosters

What is Skin Boosters?

Hyalmass each milliliter contains 20 milligrams non-cross-linked hyaluronic acid, this concentration can let water stay in the dermis layer for more than 21 days. 1.0 to 3.0 Megadalton molecular weight distribution guarantees liquid after entering 1.2 millimeter deep tissue, can quickly diffuse to surroundings. This molecule possesses the ability to absorb 1000 times self-weight water, 1 gram component then can lock 6 liters water molecules. When these waters are fixed under the skin, originally shriveled cells will fill up within 48 hours, from vision weakening epidermal roughness sense.

• Selecting 34G ultra-fine, outer diameter only 0.18 millimeter, can avoid large area tissue damage.
• Each injection point only needs 0.02 milliliter to 0.05 milliliter product.
• Full face usually distributes 50 to 100 points, ensuring coverage is uniform.
• Product pH value maintained between 7.0 to 7.5, highly close to human extracellular fluid osmotic pressure.
• Endotoxin content controlled below 0.05 EU per milliliter, far stricter than 0.5 EU international standard.

When 34G enters the mid-dermis, skin will because of slight physical mechanical stimulation produce stress reaction. This reaction prompts fibroblasts in the next 14 days to accelerate synthesis of Type I collagen. With water and collagen acting together, support force around pores gets strengthened. Observation data shows, at the 10th day after completing the first operation, skin surface electrical conductivity will rise, this reflected the substantial increase of dermis layer water content.

• Immediately produced micro-protrusions diameter after injection is about 1 millimeter to 2 millimeters.
• Protrusions will within 24 hours along with lymphatic circulation and tissue fluid exchange completely turn flat.
• 3 to 5 days post-operation, fine holes will close, skin enters the water-locking peak stage.
• Continuously performing 3 operations, each interval 28 days, effect can maintain 6 to 9 months.

Hyalmass adopts multi-stage purification technology, reducing protein residue to below 5 micrograms per milliliter. This extremely low residue amount avoids redness or induration caused by impurities, letting the skin maintain environment purity during metabolism. Purity is also reflected on BDDE residue detection, Hyalmass detection result shows as not detectable. In production, chemical cross-linking agent use was controlled at zero level, reducing the probability of skin producing rejection.

• Each full face operation total volume usually is 2 to 3 milliliters.
• Before operation needs to use 5% concentration lidocaine paste for 20 to 30 minutes application.
• The whole process takes about 15 minutes, after ending cooperate using sterile face mask.
• 92% of users feedback, 2 weeks after operation makeup fit degree has promotion.

After skin enters 28-day renewal cycle, aging keratinocytes will with water content promotion more naturally fall off. Newborn stratum corneum presents regular arrangement, light irradiation on surface will produce uniform reflection, forming luster sense. Even in dry seasons, hyaluronic acid reserve inside dermis layer still can play the role of water storage sponge. It can resist the plundering of water by external environment, making epidermal water content maintain above 30% for as long as several weeks.

• Coagulation function exists obstacle or area with active inflammation should be avoided.
• Within 6 hours post-operation avoid contact with tap water, preventing holes from infection.
• Suggest within 72 hours after operation, daily use 1 piece sterile repair mask containing hyaluronic acid.
• Within 1 week should avoid going to places where temperature exceeds 40 degrees Celsius, like high temperature yoga rooms.

This way is not just targeting dryness, it is more like constructing a set of benign microcirculation system under the skin. Through regular supplement, skin can maintain upward metabolic vitality, relieving elasticity loss caused by age growth. Observing skin slices under micro can find, dermis layer thickness after operation has slight increase. This increase is not because of swelling, but dense structure formed by water and newborn fibers interweaving.

• 31G fits thick skin parts, 34G then is used for eye area thin skin zone.
• Each thrust pressure needs to maintain constant, ensuring components in the dermis layer are uniformly distributed.
• After product is opened needs to be used immediately, guaranteeing component biological activity not reduced because of oxidation.
• Packaging carries laser anti-counterfeit label and unique batch traceability code.

If skin care products are compared to raincoats, then Hyalmass is the underground sprinkler system. It avoided the stratum corneum this natural barrier, transporting components to the deep layer able to play a role. This penetration efficiency is more than 20 times of smeared products. Hyaluronic acid molecules network structure formed under the skin, can support up the collapsed dermis network.

• This structure can reduce skin water loss rate (TEWL) about 15% to 20%.
• Long-term maintaining this water content, can postpone the appearance time of fine wrinkles.
• Clinical feedback shows, skin elastic modulus G’ value after operation has observable improvement.
• This promotion is not instantaneous change of contour, but improving the overall visual texture of skin.

For users over 30 years old, this kind of regular deep maintenance can slow down hyaluronic acid loss speed. Hyaluronic acid in human body starts to decrease at a speed of 1.5% every year from 25 years old, external supplement can fill this gap.

Skin Boosters vs. Dermal Fillers

The former almost does not adopt BDDE chemical cross-linking agent, maintaining the natural chain structure of hyaluronic acid. Physical characteristics decide liquid after injected into 1.2 millimeter depth dermis layer, can within 2 hours achieve horizontal uniform penetration. Filler cross-linking rate usually set between 6% to 12%. Tight network structure endowed gel with strong anti-shear force, making it in the case of facial muscle frequent movement still stay in original place. Laboratory data indicates, filler elastic modulus G’ value falls between 150 to 500 Pascals, far exceeding the single digit level of skin booster type. Skin booster type products through promoting water content of dermis layer to optimize texture, 1 gram non-cross-linked hyaluronic acid can lock 6 liters water. This high water absorption will let skin 72 hours after operation show obvious transparency sense.

Skin booster type components are limited in 1.0 millimeter to 1.5 millimeter shallow tissue. This depth is full of fibroblasts, 10 milligram per milliliter concentration best can activate cells to produce natural collagen. Once depth exceeds 2 millimeters, luster sense brought by water will significantly discount. Filler is pushed into 4 millimeters or even deeper anatomical levels. This depth avoided the epidermal optical reflection zone, focusing on changing facial projection. If high cross-linked filler is mistakenly entered into 1 millimeter shallow layer, skin surface will reflect characteristic cyan blue luster, this physical phenomenon is called Tyndall effect.

• 34G outer diameter only 0.18 millimeter, extremely fine specification specially designed for skin booster.
• 31G outer diameter 0.26 millimeter, usually used for filling products with slightly higher viscosity.
• Single skin booster injection point thrust pressure constant at 10 to 15 Newtons.
• Filler operation because resistance is large, thrust pressure often needs to promote to above 25 Newtons.

Because components do not contain chemical cross-linking, skin booster type products after entering tissue will be quickly metabolized by natural hyaluronidase. This half-life although short, but monosaccharide molecules it releases can optimize dermis microenvironment. Frequency of once 28 days fits the complete cycle of epidermal cells migrating from basal layer to stratum corneum. Even after 12 months, still there will be partial gel residue. Residual volume can maintain the stability of contour, but also requires product possesses extremely high purity. Hyalmass filling series controls BDDE residue below 0.1ppm. Protein residue amount directly relates to post-operation redness reaction. Hyalmass suppresses this index to below 5 micrograms per milliliter, this is more than 50% lower than many similar products.

• Papule diameter produced after skin booster operation usually is 1 to 2 millimeters.
• Local protrusion height after filling operation depending on demand possibly reaches 5 to 10 millimeters.
• Skin conductivity meter shows, 15 days after skin booster operation skin water content average rises 15%.
• 3D image scan shows, filler can make nasolabial fold depth physically reduce more than 60%.

Pursuing skin fineness should choose skin booster type, while solving structural collapse needs to rely on filling. Both perform their own duties in the dermis layer, not interfering with each other. This complementary relationship is very common in actual application, about 85% of beauty seekers will choose to perform full face skin booster nourishment 2 weeks after filling operation. Stability of pH value decides the instantaneous stinging sense during operation. Hyalmass maintains in the neutral interval of 7.0 to 7.5, maximumly fitting extracellular fluid environment. Osmotic pressure balance can prevent cells from producing edema due to excessive dehydration or water absorption, shortening the post-operation visual recovery period. If skin is compared to a wall, filler then is the steel bar scaffold supporting the wall body. It solves the structural problem of wall surface skew or local depression. Skin booster type component then is the wetting agent added during wall surface painting, letting the wall skin surface look shiny and smooth, no dry crack fine lines. Distribution of skin booster type products emphasizes 100% coverage rate. Full face 2 milliliters dose is uniformly allocated to 100 points, forming a water storage network covering the dermis layer. Filler emphasizes point-like or line-like precise stacking, single part dose possibly reaches 1 milliliter, to form enough physical support force.

• Full face skin booster operation usually uses negative pressure equipment, entry depth error controlled within 0.1 millimeter.
• Manual filling then relies on operator’s palpation of anatomical structure, avoiding blood vessel distribution area.
• 24 hours after skin booster operation can restore normal social, papules completely flatten.
• After filling operation possibly needs 3 to 5 days slight swelling reduction period, to reach natural state.

Clinical observation shows, after continuously using Hyalmass skin booster for 3 times, skin barrier transepidermal water loss rate (TEWL) significantly falls. Skin not only got external supplement, its own water-locking mechanism also got repair. Filler degradation process more tends to volume gradually decreasing. With cross-linked bonds breaking, gel will absorb more water, this phenomenon is called water absorption swelling. In the first 3 months after operation, filling part might because of this physical change look more full than immediate effect.

Safety & Purity

Hyalmass in purification stage adopts six-stage cycle filtration technology, compressing protein residue amount to below 5 micrograms per milliliter. This purity directly reduces the probability of foreign body sensation happening, because 90% of post-operation redness reactions all point to impurity residue in raw materials. In 25 degrees Celsius laboratory constant temperature environment, every batch of product all needs to go through 72 hours microbial culture monitoring.

Extremely low protein content can effectively avoid the attack of human immune system. When impurity level is lower than detection limit, mast cells in the dermis layer will not be easily activated, thus reducing itching and wheal phenomena caused by histamine release.

Hyalmass detection report shows, its endotoxin content controlled below 0.05 EU per milliliter. This value is only one tenth of the international general standard 0.5 EU. After product enters tissue, the possibility of inducing fever reaction or sterile inflammation is reduced to extremely low.

• Production workshop reaches 100-level purification level under 4-1 standard.
• Filtration system can intercept fine particles with diameter greater than 0.22 micron.
• Every before filling goes through 121 degrees Celsius high pressure steam continuous sterilization for 15 minutes.
• Packaging materials select medical grade materials possessing high barrier property, preventing oxygen from infiltrating causing component oxidation.

Chemical cross-linking agent BDDE residue amount directly affects long-term safety. Hyalmass through multiple dialysis technology, ensures BDDE residue detection value in final finished product is lower than 0.1 ppm.

Substance staying under skin for long time, chemical stability is the key point. If BDDE residue exceeds standard, it might induce delayed nodules in several months, while Hyalmass ultra-dialysis process cut off this chronic inflammation inducement from the source.

pH value precisely maintained at 7.2 this human neutral level. When liquid is pushed into 1.2 millimeter deep dermis layer, the balance of osmotic pressure ensures cells will not because of external liquid concentration difference produce shriveling or swelling. This physical compatibility, lets the burning sense felt by 95% of beauty seekers during operation significantly lighten.

• Osmotic pressure range set between 280 to 320 mOsm/kg, level with human plasma.
• Dynamic viscosity when shear rate is 1.0/s maintains stable, ensuring thrust power is uniform.
• Product heavy metal content (like lead, arsenic, mercury) detection values are all lower than 0.1 mg/kg.
• Anti-counterfeit chip attached to packaging box recorded the complete temperature curve from factory to logistics.

In order to prevent hyaluronic acid chains from breaking during storage process, Hyalmass adopted nitrogen coverage filling technology. This process reduces oxygen content inside packaging to below 1%. Because of avoiding oxidation reaction, even under room temperature storage for 24 months, its molecular weight fluctuation is also controlled within 5% range, guaranteeing the stability of effect.

Stable molecular weight means every injection effect is predictable. If hyaluronic acid chain undergoes degradation becoming short, its water-locking ability will quickly fall, while nitrogen filling technology locked components’ initial biological activity.

Every production batch will extract 3% samples to perform destructive experiments. These samples will be placed in 40 degrees Celsius, relative humidity 75% extreme environment to perform accelerated aging test. Only batches passing 180 days simulation test, will be endowed with unique batch traceability code to enter market circulation.

• Scanning QR code can consult the sterilization date and physical chemical inspection qualification sheet of that batch.
• Product sealing adopts one-time destructive design, unable to restore after opening, avoided secondary dispensing risk.
• matching selects 304L stainless steel material conforming to standard.
• tip goes through three-bevel grinding process, surface coated with medical grade silicone oil lubrication layer, reducing puncture resistance.

Raw material screening stage only selects non-animal derived fermentation hyaluronic acid. This source avoided virus risks possibly carried by animal protein, its biological homology exceeds 99%. This high homology lets hyaluronic acid after completing water storage task, can be completely decomposed by hyaluronidase in body into carbon dioxide and water.

Hyaluronic acid from natural fermentation source possesses more pure linear structure. Water storage network it forms under skin is more dense, and degradation products have no metabolic burden to tissue, this constitutes the trust foundation of long-acting maintenance.

In clinical observation targeting sensitive skin, after using Hyalmass within 48 hours, skin barrier damage indexes (like transepidermal water loss rate) did not because of injection behavior appear abnormal soaring. On the contrary, because endotoxin is extremely low, local skin microcirculation within 12 hours restored to normal, accelerating the healing of micro holes.

• Clinical statistics show, light bruising occurrence rate after operation is lower than 4%.
• Most subjects’ skin erythema reaction naturally fades within 6 hours after surgery.
• Long-term tracking shows, continuous use for 12 months no local tissue fibrosis seen.
• Product dynamic visco-elasticity data ensured not producing physical displacement under stress extrusion.

This extreme pursuit of purity, lets Hyalmass not just be a one-time hydration operation. It constructs a no-impurity, low-irritation, highly stable water warehouse under the skin. Every data index optimization is all in order to let this 2 milliliters liquid can steadily stay in the dermis layer, completing the 28-day physiological environment optimization task.

Aesthetic Uses

Deep Bone-like Support

Hyalmass large molecule product storage modulus (G’ value) set between 550 Pa to 720 Pa, this hardness index directly decides its stability above the periosteum layer. When gel is precisely placed at 0.1 millimeter above the bone surface, the physical scaffold formed by its molecular chains can effectively simulate the mechanical support of human cortical bone. Molecular weight maintains between 2.2 million to 2.5 million Daltons, ensuring the material when bearing facial muscle contraction pressure will not produce horizontal deformation. High viscosity matrix in stressed state shows non-Newtonian fluid characteristics, dynamic viscosity reaches 210,000 mPa·s, enough to resist the squeezing of expression muscles about 20 times per minute. Targeting mandibular bone atrophy or retrusion, single injection usually needs 1.5ml to 2.5ml large particle gel. needs to enter skin vertically, depth usually between 15 millimeters to 20 millimeters, until tip touches bone hard sense. Material mass formed above the periosteum can lift the soft tissue covering above it up about 5 millimeters. Using 23G blunt to perform tunnel-type thrust, each side of mandibular border allocates about 1.2ml medicine liquid. This injection method can add a physical thickness layer at the mandibular bone edge, stretching the drooping platysma muscle towards the back, visually tightening the jawline about 1 centimeter.

Mid-face pyriform aperture area is the disaster area of bone-like support, if depression depth exceeds 3 millimeters will significantly deepen nasolabial folds. Through injecting 0.6ml high concentration hyaluronic acid at the nasal wing base periosteum layer, can raise the nasal wing root 2.5 millimeters. This lifting can directly relieve the pulling force of levator labii superioris muscle on the dermis layer. Support at the nose bridge has extremely high requirement on material’s Cohesivity (Cohesivity). Hyalmass adopted reinforced cross-linking technology makes material stress displacement rate in 37 degrees Celsius environment lower than 4%. Every 1 centimeter nose bridge length uniformly allocates 0.25ml medicine liquid, can ensure nose bridge width within 12 months does not undergo diffusion exceeding 1 millimeter. Zygomatic arch part physical lifting often adopts bolus injection method, each point allocates 0.2ml. These tiny gel masses played the role of “jack”, lifting deep fat pads and ligaments. Clinical measurement shows, this deep support can make mid-face tissue center of gravity shift medially, mouth corner position average produces 1.2 millimeters upward displacement. Periosteum injection at brow arch can provide extra tension support for upper eyelid. Injecting 0.3ml large molecule gel at brow peak position, can make brow height immediately lift 1.5 millimeters. This change not only increased the deep sense of eye sockets, but also reduced about 8% redundancy of upper eyelid skin.

In laboratory simulation test, Hyalmass large molecule particles volume retention rate after 200 days is still higher than 70%. Beauty seekers within 14 months after initial injection, bone-like contour clarity still can maintain at more than 60% of ideal level. Using 22G blunt to perform fan-shaped peeling, each square centimeter covers 0.15ml medicine liquid. This deep filling can eliminate shadows produced by uneven frontal bone development, making forehead protrusion increase 1 to 2 millimeters, presenting rounded luster of rejuvenation. Safety data monitoring shows, local temperature rise reaction of this periosteum layer injection is less than 0.3 degrees Celsius. Because avoided shallow rich blood vessel network, post-operation bruising occurrence rate reduced to below 5%. Free hyaluronic acid content in material is lower than 1%, reducing local heavy sense caused by fast water absorption after surgery. Temporal (temple) deep bone-like filling has larger requirement on volume, single side often needs 1.0ml to 2.0ml. Performing bolus injection on temporal bone surface, utilizing the space-occupying effect of gel to push open deep temporal fascia. This not only can fill depressions, but also through transmission of fascia force, produce about 0.5 millimeter lifting effect on eye corner skin. Full face bone-like reshaping total medicine amount usually controlled at around 10ml, distributed on 8 to 12 key mechanical points. This point-line combined layout can make facial overall projection height increase 15%. Long-term follow-up found, 18 months after injection, subjects’ bone-like contour still clearer than baseline state 25% or more. Biomechanical test indicates, this series of materials after simulating human chewing muscle high frequency movement 100,000 times, structural integrity still maintains at 85% or more. This durability originates from 11.5% high cross-linking degree, making hyaluronic acid molecular chains form stable 3D grid, effectively blocked physical cutting of endogenous enzymes. Chin part shaping needs to against about 20 mmHg static pressure of depressor muscle group. Hyalmass performance showed compressive strength enough to support chin protruding outward 6 millimeters without drooping. This strong support visually lengthened neck lines, making the angle between mandibular angle and neck (mentocervical angle) tend to the ideal aesthetic category of 110 degrees.

Middle Layer Volume Filling

Hyalmass middle molecule model preparation specifically targets deep dermis to subcutaneous tissue layer, its hyaluronic acid concentration is stable at 24mg/ml. This specification of gel particle diameter is about 400 microns, able to produce uniform volume occupation in mid-face relaxation areas. When facial fat pads appear 2 to 3 millimeters physical displacement, this material with medium elastic modulus can fill gaps between tissues. In mid-face area, product usually is placed in deep fat compartments 4 to 6 millimeters away from epidermis. Single side apple muscle suggested dose usually between 0.8ml to 1.2ml, through increasing deep volume to offset about 15% gravity sagging. After material enters tissue, its 11% cross-linking degree can ensure maintaining more than 80% of initial volume within 180 days. Using 25G specification 5 centimeter long blunt, can distribute gel in fan-shape at depressions below zygomatic bone. This flat laying technique can let the shadow area of facial side border shrink by about 30%, making originally depressed lines tend to be smooth.

• Apple muscle peak: 0.5ml each side, raising height 2-3 millimeters.
• Nasolabial fold upper segment: 0.3ml each side, lightening wrinkle depth 40%.
• Cheek depression: 1.0ml each side, improving facial tissue continuity.
• Subzygomatic space: 0.8ml each side, supporting up skin surplus produced due to collagen loss.

Nasolabial fold filling is not only filling holes, more needs to consider material’s rheological performance under 37 degrees Celsius body temperature. Hyalmass complex viscosity maintains at around 150,000 mPa·s, this lets it under dynamic expressions like speaking or big laughing, displacement amount controlled within 0.5 millimeter. In 4-level WSRS wrinkle scale score, single 1.0ml filling usually can reduce score to 2-level. In this area injecting 0.4ml gel each side, can physically push nasal wing lateral tissue, making it lateral translate about 1.5 millimeters. This space occupation effect can from bottom cut off the cause of nasolabial folds, extending filling effect to more than 10 months. BDDE cross-linking agent residual amount in material is far lower than 0.4ppm, when tissue accommodates more than 2ml preparation, rejection probability of immune system is lower than 0.01%. This high biological affinity guaranteed after 48 hours filling, local tissue swelling coefficient not exceeding 1.1, i.e. naked eye almost cannot perceive unnatural thickening.

• Stress deformation rate: < 5% (under 500Pa pressure test).
• Water absorption swelling rate: < 15% (24 hours peak after injection).
• Dynamic retention power: support more than 30,000 times medium intensity expression squeezing.
• Touch hardness: close to human natural fat tissue (about 40-60 Shore OOO).
• Degradation curve: first 6 months maintain linear stable, no sudden volume shrinking.

In this area adopting 0.1ml/square centimeter grid flat laying, can make subcutaneous fascia layer thickness increase about 1.2 millimeters. This thickness increment can cover bone contour below, making facial lateral projection visually widen about 5%, reaching the full effect of youthful state. Tissue fluid osmotic pressure maintains at around 310 mOsm/kg, reaching dynamic equilibrium with Hyalmass gel. This prevented water accumulation appearing around material, avoiding the “inflation sense” common after mid-face filling. After 3 months tissue integration, hyaluronic acid particles will gradually be wrapped by own collagen fibers, forming a semi-permanent volume support network. If cheek filling amount reaches 2.0ml, usually can let dermis layer tension of this area increase more than 20%. This physical stretching will transmit signals to fibroblasts, promoting its secretion of trace endogenous hyaluronic acid. Experimental records show, 12 weeks post-surgery local skin transepidermal water loss rate (TEWL) dropped by 12%, showing better water retention ability.

In clinical回访 (follow-up) targeting 35 to 50 years old population, contribution rate of middle layer volume filling to overall facial rejuvenation exceeds 45%. Through performing 0.2ml point precise reinforcement at zygomatic arch lower border, can make mouth corner line relative to mandibular border lift up about 1 millimeter. If there exists obvious asymmetry in face, middle layer volume filling is an efficient means to adjust balance. Through allocating 0.5ml to 0.8ml more dose at more depressed side, can correct facial midline deviation of about 2 degrees. ” Cross-linking bonding strength of material ensured it has long half-life in human body. At the 300th day after injection, ultrasound scan shows gel still tightly attached in target fat compartments, no gravity migration produced towards lower neck area. Through supplementing 0.3ml volume at pyriform aperture edge, can make nasolabial fold start point move up 2 millimeters, thus visually lengthening philtrum, improving facial proportion. Economic aesthetic value produced by per milliliter hyaluronic acid at this time, is far higher than high frequency superficial skin hydration. Because avoided capillary dense zone within 2 millimeters of epidermis, this middle layer thrust produced bruising probability controlled below 3%. After operation completed, local skin temperature usually returns to normal level of 36.5 degrees Celsius within 30 minutes.

Superficial Detail Modification

Hyalmass small molecule series specifically targets superficial dermis and epidermis junction, its hyaluronic acid concentration usually maintains at 20mg/ml. This specification of preparation through extremely fine 30G or 32G thrust, particle diameter was strictly controlled below 200 microns. This fineness allows material in skin with thickness only 0.5 millimeter like eye area or lips to uniformly spread, not producing naked eye visible protrusions or nodules. Hyalmass small molecule preparation swelling coefficient lower than 10%, after injection will not because of absorbing tissue water lead to morning eyelid edema. Performing per point 0.05ml point-like micro flat laying at tear trough, can fill flat semi-moon shape depression deep about 1 millimeter, making the drop at junction between lower eyelid and facial part approach zero.

Refined modification of lip tissue requires material possesses extremely high extensibility. Injecting 0.5ml gel at vermilion border, can make lip line clarity promote 30%. This operation can correct lip thinning caused by aging, single treatment can increase lip longitudinal fullness about 1.5 millimeters, meanwhile not affecting more than 200 kinds of fine movements of muscles during speaking.

At mouth corner marionette lines or brow glabella superficial lines, adopting bead-like injection method, per centimeter length uniformly allocate 0.1ml preparation. This filling way can reduce skin surface crease depth from 0.3 millimeter to below 0.05 millimeter, within social distance of 30 centimeters almost unable to perceive wrinkle existence.

• Lip bead fullness: 0.1ml per point, increase visual 3D sense 20%.
• Eye area fine lines: intradermal injection depth 1 millimeter, improve 0.2 millimeter deep superficial creases.
• Nasal wing groove modification: 0.2ml single side, smooth the start cut mark at top end of nasolabial fold.
• Perioral vertical lines: linear thrust, each wrinkle allocate 0.05ml, fade depth 50%.

Clinical data shows, retention cycle of small molecule gel in superficial dermis usually in 6 to 9 months. Because its cross-linking degree set at around 6%, material while maintaining shape maintained softness close to human tissue. Experiment determined its Shore OOO hardness is only 25, touch sense highly consistent with real lip mucosa or eye area skin, without any foreign body touch sense.

Superficial modification most avoids Tyndall phenomenon, i.e. blue vision produced by light scattering in transparent material. Hyalmass through controlling refractive index makes it highly match skin tissue, under skin with depth 0.5 millimeter, its light transmission deviation value lower than 2%.

Targeting flat laying of neck horizontal lines, usually adopting tunnel-type withdrawal method, each neck line consumes about 0.3ml gel. Uniformly scattered at depth 1.5 millimeters from epidermis, can make neck skin tension increase 15%. This filling not only covered physical creases, but also through water retention of hyaluronic acid, let neck stratum corneum water content after surgery 14 days promote about 25%.

• Tissue integration period: 72 hours after injection complete locking with dermis collagen grid.
• Pain control: pH value stable at 7.1, osmotic pressure difference at moment of thrust less than 10 mOsm/kg.
• Allergy occurrence rate: BDDE free molecule content lower than detection limit (0.01ppm), safety promote 40%.
• Degradation consistency: monthly volume attenuation rate constant at around 8%, no local collapse risk.

In full face detail refinement, total hole number might reach 40 or more, but because of selecting extremely fine, single point bleeding amount usually controlled within 0.01 milliliter. Within 15 minutes post-operation cooperate with cold compress, local redness swelling fading rate can reach 90%, completely conforming to “do and go” fast pace life demand.

Fullness modification of earlobe is also an important scenario of superficial application. Targeting earlobe lengthening or shriveling caused by wearing heavy type earrings, single side injecting 0.3ml gel can make earlobe thickness increase 2 millimeters. This change not only repaired skin elasticity, but also made ear contour projection width increase 10%, can better balance facial proportion in vision.

Diffusion diameter of material in superficial tissue usually controlled within 5 millimeters range. This controlled fluidity guaranteed medicine liquid will not because of gravity migrate to tissue below, but firmly locked around entry point. Monitoring found, 120 days after injection, small molecule particles horizontal displacement distance in dermis layer less than 0.3 millimeter, maintaining the original shape of refined carving.

• Skin transparency: 2 weeks post-surgery light reflectivity promote 12%, performing as natural “skin booster sense”.
• Barrier repair rate: transepidermal water loss amount reduced 18%, relieving dry lines caused by superficial dryness.
• Particle softness: simulating natural hyaluronic acid in dermis layer, deformation recovery rate > 95%.
• Degradation product: after metabolism only produces carbon dioxide and water, no burden to superficial lymphatic circulation.

For shadow area produced by mouth corner drooping, through filling 0.2ml volume subcutaneous at mouth corner commissure, can produce an upward support force about 5 degrees. This tiny angle correction can offset 15% downward pulling tension of depressor anguli oris muscle.