How to Use Xeomin for Underarm Hyperhidrosis | Dosage Guidelines, Efficacy Duration, and Patient Satisfaction

Xeomin is used for axillary hyperhidrosis, routine dose 50U per side (total 100U), intradermal multi-point injection (about 10–15 points). Efficacy is usually 3–6 months, onset in 1 week, peaks in 2 weeks. Research shows about 80% of patients have sweat reduction ≥50%, high satisfaction. Need to mark the sweating area, distribute injection evenly, avoid too deep.

Dosage Guidelines

Clinical Quantification

100 units of Xeomin are encapsulated in a sterile vacuum, appearing as visible extremely fine white powder. The reconstitution process needs precise injection of 2.5 ml of 0.9% sodium chloride solution. During operation, saline should be pushed slowly along the wall, violent shaking is strictly prohibited to prevent the 150kDa active molecular structure from damage due to shear force. The concentration of the diluted medicinal liquid is 4 units per 0.1 ml. For bilateral armpits, usually 50 units are allocated to each side. If the measured sweating area of a single side armpit exceeds 60 square centimeters, the total dose needs to be adjusted to 150 units. This ensures the medicinal liquid covers a concentration of about 2.5 units per square centimeter.

• Use 30G specification ultra-fine injection to reduce tissue damage
• Match with 1 ml specification low dead space piston
• Use 75% concentration isopropyl alcohol for local skin surface cleaning
• Maintain an operation environment of room temperature 20 to 25 degrees Celsius
• Keep tip bevel upward and pierce at a 15-degree angle

Apply 5% concentration iodine solution to the dry armpit, after drying evenly sprinkle fine corn starch. Within 3 to 5 minutes, moisture discharged from active sweat glands will trigger color change, turning yellow powder into deep purple-black. Use a marking pen to draw a 1.5 cm by 1.5 cm square matrix within the dark area. Usually 20 to 25 cross-injection points are formed in each side armpit. Each point is planned to inject 0.1 ml of medicinal liquid to ensure the drug diffusion radius can effectively cover all sweat gland tissues within the square. The insertion depth must be strictly controlled at 2 mm in the deep dermis. tip bevel upward, only piercing the skin surface layer. With the steady release of injection pressure, a pale white bulge with a diameter of about 2 to 3 mm will immediately be produced on the skin surface; this kind of wheal is the physical signal that the medicinal liquid is precisely delivered to the sweat gland nerve endings.

• Avoid insertion depth exceeding 3.5 mm into the fat layer
• Control travel interval error within 1.5 mm
• Single point dose deviation should not exceed 0.5 units
• Each injection time is maintained at 1 to 2 seconds
• Avoid micro blood vessels clearly visible under the skin

Xeomin molecules begin to bind with SNAP-25 protein within 12 hours after injection. This protein is the medium for releasing acetylcholine, and acetylcholine is responsible for sending sweating electrical signals. Observation data shows that 48 hours after operation, sweat volume decreases by more than 60% on average. At one week, the inhibition rate reaches its peak, sweat reduction is usually in the 90% to 95% range. A 100-unit dose can maintain this dry state for 180 to 270 days, the duration depends on the individual’s nerve ending repair speed. Long-term follow-up records show that after receiving 3 quantitative operations continuously, the maintenance cycle of some people can be extended to 300 days. The second intervention is suggested to be performed when the first effect subsides by 50%, usually selected around the 24th week.

• Rubbing or squeezing the injection area is prohibited within 6 hours
• Keep the armpit area absolutely dry within 12 hours
• Do not use solid antiperspirants containing aluminum salts within 24 hours
• Avoid strenuous upper limb extension exercises within 48 hours
• Record the sweating percentage on the 3rd and 14th days after surgery

The tiny holes left on the skin surface will close naturally within 4 hours. The local dose of 100 units is only a very small proportion of the systemic toxic dose, the safety factor is extremely high. Compared to the method of cutting nerves, this quantitative micro-injection method will not cause permanent tissue compensation or abnormal sweat migration. If the area of a single side armpit is small, the dose can be compressed to 40 units. Excessive local concentration will lead to medicinal liquid diffusing towards deep muscles. If the medicinal liquid enters the muscles on the inner side of the arm, it may cause a brief feeling of weakness in holding objects. Maintaining the strictness of the square matrix is an effective means to avoid medicinal liquid accumulation. The reconstituted medicinal liquid activity decays by about 3% per hour at room temperature. The opened vacuum should be used up within 8 hours. If short-term preservation is needed, it should be placed in a refrigerated environment of 2 to 8 degrees Celsius. Immediate preparation and use can ensure each 100 units of Xeomin exerts the expected sweat inhibition efficacy.

Reconstitution Ratio

100 units of Xeomin powder are attached to the bottom of a 5 ml specification, the thickness is usually less than 1 mm. This pure type botulinum toxin does not contain any complexing proteins, the molecular weight is constant at 150kDa. During reconstitution, 0.9% physiological saline without preservatives must be used to ensure the osmotic pressure of the solution completely matches human tissue fluid. If negative pressure sensation is missing, it indicates the stopper seal is damaged, and the drug efficacy might be reduced due to oxidation. The speed of sucking in saline should be controlled at 0.5 ml per second, avoiding strong liquid flow impacting the protein crystals at the bottom. The pH value of physiological saline should be between 5.0 and 7.0. During the preparation process, slowly injecting 2.5 ml of saline along the wall is the clinically recognized standard operation. Dissolve the powder by slightly rotating the body, violent up and down shaking is strictly prohibited. Excessive mechanical shear force will destroy the disulfide bond structure of the neurotoxin, leading to a decrease in biological activity for inhibiting sweating.

• When reconstitution volume is 1.25 ml, every 0.1 ml of liquid volume contains 8 units
• When reconstitution volume is 2.5 ml, every 0.1 ml of liquid volume contains 4 units
• When reconstitution volume is 5.0 ml, every 0.1 ml of liquid volume contains 2 units
• Standard drug delivery volume for single side armpit is 1.25 ml to 2.0 ml of solution
• 100 units of Xeomin are usually diluted to 4 ml to 5 ml total volume

Handling of sweating issues tends towards medium-high volumes, because sweat glands in the armpit present as a reticular spread rather than concentrating at a single point. Increasing dilution water volume can improve the coverage breadth of the medicinal liquid in the dermis layer and reduce the probability of missed injections. If the area of a single side armpit is 60 square centimeters, using the 4.0 ml dilution scheme can ensure each square centimeter obtains about 0.06 ml of medicinal liquid. This distribution density can let Xeomin molecules evenly infiltrate into nerve junctions around every sweat gland duct.

• Select 1 ml specification with low dead space
• Scale is accurate to 0.01 ml to support micro-dose injection
• When exhausting air bubbles, avoid losing more than 0.02 ml of medicinal liquid
• Injection is suggested to choose 30G or 32G extremely fine model
• Each of drug powder is suggested to complete extraction within 30 minutes after dissolution

The prepared Xeomin solution is transparent and colorless, and should not show suspended particles or turbidity. In a room temperature environment of 20 degrees Celsius, the activity of the acetylcholine receptor blocker will slowly decrease over time. Data shows that if placed for more than 24 hours after reconstitution, the onset speed of sweat inhibition will be delayed by 2 to 3 days. Unused diluted liquid must be stored in a refrigerator at 2 to 8 degrees Celsius. If the ambient temperature exceeds 30 degrees Celsius, the spatial conformation of protein molecules will undergo irreversible changes. Saline placed for too long may have a pH offset due to carbon dioxide dissolution, which in turn changes the dissociation state of Xeomin. The saline error corresponding to every 100 units of drug powder should be controlled within 0.05 ml; this precision can ensure the sweat inhibition intensity of both side armpits remains symmetrical.

• The total dose allocation ratio for both side armpits is 1 to 1 for 50 units each
• When the operation area is asymmetrical, allocate according to 1.5 units per square centimeter
• insertion depth is locked at 2.0 mm in the deep dermis layer
• Injection pressure should be kept uniform to prevent subcutaneous tissue from producing a tearing sensation
• The entire operation needs to avoid the medicinal liquid contacting direct strong light

The medicinal liquid diffusion diameter produced by this reconstitution scheme is about 1.2 cm. Injecting within a 1.5 cm interval grid, the medicinal liquid edges can achieve physical overlapping coverage. This overlapping effect eliminates blank zones between sweat glands and is the technical prerequisite for achieving a 100% dry area in the armpit after treatment. If the single point injection volume is set to 0.1 ml, combined with a 2.5 ml dilution ratio, 25 points can be arranged in a single side armpit. For stubborn hyperhidrosis, the single point dose can be fine-tuned to 0.12 ml while the total number of points remains unchanged. This adjustment can increase the local nerve ending drug load and prolong the sweat signal blocking duration. The viscosity of the medicinal liquid after preparation is close to physiological saline, and injection resistance is extremely small. If obvious resistance is felt during injection, it usually suggests the tip position is too shallow entering the epidermal stratum corneum, or too deep touching the muscle fascia. Standard performance should be the skin surface quickly bulging a translucent, slightly hard flat blister.

• Total time consumption of reconstitution process is controlled within 120 seconds
• stopper disinfection needs to use 75% ethanol and air dry naturally
• After extracting medicinal liquid, replace with a new to maintain sharpness
• The residual 0.05 ml of medicinal liquid in the discarded needs to be destroyed as bio-waste
• Prohibit mixing Xeomin from different batches in the same

The final formed 50-unit medicinal liquid contains about 0.22 nanograms of neurotoxin pure protein. Since Xeomin removes complexing proteins through a high-purification process, its stability in a diluted state is more sensitive to the environment. Ensuring the reconstitution environment is sterile and at a constant temperature is the underlying logic for guaranteeing a continuous dry efficacy of more than 6 months after treatment. Since the thickness of the axillary dermis layer has a difference of about 0.5 mm between different genders, the osmotic pressure of the diluted liquid will also affect the absorption speed. Male skin is thicker, so saline can be appropriately reduced by 0.5 ml during reconstitution to increase the osmotic pressure of unit concentration. Female skin is thinner, increasing the dilution ratio can effectively reduce the swelling pain sensation during single point injection. The medicinal liquid completes preliminary diffusion 15 minutes after being injected subcutaneously. The precision of the reconstitution ratio directly determines the molecular movement trajectory within these 15 minutes.

Injection Points

A single side armpit is usually divided into a rectangular area of about 50 to 70 square centimeters. Before marking, ensure the skin is dry, use 5% concentration iodine tincture to evenly apply to the armpit hair distribution area and a range 1.5 cm outside its edge. Moisture discharged from sweat glands will quickly transform the yellow-brown surface into deep purple-black. These dark patches indicate the target zones where sweat glands are most densely distributed. Usually at the center point of the armpit, the color is deepest, representing about 100 to 150 active sweat glands distributed per square centimeter.

The sweat gland density at the top area of the armpit is the highest, and injection points need to be more compact here. When spreading to the edges, sweat volume presents a gradient weakening.

Measure the length and width of the color-changing area, use a surgical marking pen to draw a 1.5 cm by 1.5 cm grid. For subjects of average body type, a single side armpit can usually arrange 20 to 25 intersection points. Each point is an independent Xeomin injection station. The neatness of the grid determines the uniformity of drug diffusion. Under the 2.5 ml dilution scheme, each intersection point is planned to inject 0.1 ml of medicinal liquid, which contains about 4 units of active ingredients. This distribution pattern can let the medicinal liquid form a coverage ring with a diameter of about 1.2 cm under the skin.

• choice 30G ultra-fine specification, length controlled within 4 mm
• entry point is located directly above the intersection of grid lines
• Maintain single point injection volume deviation within 0.01 ml range
• Total number of injection points on a single side is not suggested to exceed 35
• A row of sparse points needs to be added at 1 cm outside the armpit hair edge area

Insertion depth must be locked deep in the dermis layer, about 2.0 mm position. tip bevel upward, sliding into subcutaneous at a 15-degree angle. As the thumb presses down at a steady speed, the skin surface should bulge a white wheal with a diameter of 3 mm. This physical protrusion marks that the medicinal liquid has precisely surrounded the base of the sweat gland duct. If there is no resistance when pushing and no wheal is seen, it indicates the has penetrated the 3 mm thick dermis layer and entered the fat pad. At this time, Xeomin molecules will flow towards deep tissues and cannot effectively block the acetylcholine receptors of the sweat glands. Single point drug delivery time should be controlled at about 1.5 seconds to prevent tearing sensation in subcutaneous tissue due to excessive pressure.

The thickness of the junction between the dermis layer and the fat layer is about 3.5 mm, which is the lower limit of nerve ending distribution.

Observe the local reaction after completing each row of points. Normal wheals will gradually flatten within 20 minutes, which marks that the medicinal liquid begins to diffuse to tissues within a 1.0 cm radius. Physical overlap between points is the technical prerequisite for ensuring 100% dry coverage. The sweating areas of left and right armpits often have a difference of 10% to 15%. On the total dose allocation of 100 units, flexible adjustments should be made based on starch-iodine color results. If the color area on the left is 5 square centimeters more than the right, 5 units can be transferred from the right to the left to maintain symmetry of sweat inhibition intensity on both sides.

• Avoid entering at superficial positions with visible fine blood vessels
• Point arrangement needs to be performed after stretching the skin at deep armpit creases
• After each point injection is completed, the needs to stay for 1 second before being pulled out
• Local hematoma with a diameter exceeding 5 mm should not appear in the operation area
• Drug load at a single grid point should not exceed 6 units

After Xeomin molecules enter the dermis layer, they will diffuse outwards through molecular thermal motion. Under the 1.5 cm grid system, diffusion edges of adjacent points will produce about 0.2 cm of overlapping coverage. This density can cut off more than 95% of nerve signal transmission. For subjects with vigorous armpit hair growth, sweat gland distribution often exceeds the range visible to the naked eye. Outside the main target area, a “plum blossom pile” type of supplementary point method needs to be adopted, and the interval can be expanded to 2.0 cm.

Male armpit skin thickness is usually 0.4 mm thicker than females, and the resistance of entry sensation is more obvious.

Injected medicinal liquid completes molecular binding with SNAP-25 protein within 48 hours. 100 units of Xeomin under grid-like distribution can cover about 12,000 active sweat gland units. Clinical data shows that this point layout can reduce local sweat volume from a baseline value of 50 mg per minute to below 5 mg. The whole operation needs to maintain the subject’s upper limbs abducted at 90 degrees to fully expose the injection target area. If the armpit skin is loose, use the left index and middle fingers to tighten the target grid point. Flat skin tension can ensure the 2 mm entry depth does not offset, reducing accidental injury to the microvascular network under the dermis.

• needs to be kept horizontal when moving between each point
• Repeated drug delivery at the same hole is strictly prohibited
• If micro bleeding occurs, immediately press with a dry cotton ball for 30 seconds
• After operation is finished, wheal distribution density needs to be checked through transmitted light
• should be replaced every 10 uses to maintain piercing sharpness

The osmotic pressure of the medicinal liquid is highest at the moment of injection and then decays rapidly. Through the physical arrangement of grid points, an invisible drug protection net is actually constructed under the skin. This spatial distribution accurate to the millimeter directly determines the dry quality of the armpit environment within 180 days after surgery. If the subject has a history of surgery or local scars, points need to bypass fibrotic tissue. Sweat glands at scars usually have lost function, and hardened tissue will hinder the medicinal liquid from diffusing to the surroundings. Adding a 0.5 unit dose at the edge of the scar can compensate for the diffusion loss caused by tissue resistance.

Efficacy Duration

Onset Timeline

After the medicinal liquid enters the 1.5mm dermis layer under the skin, the diffusion process immediately starts. In the first 24 hours, Xeomin molecules look for acetylcholine receptors within the tissue gaps. Axillary sweat volume shows a visible decrease at the 48th hour, and moisture secretion intensity usually shrinks by more than 20%. From the 3rd to the 5th day, the wet area of the shirt armpit region obviously narrows. The original palm-sized sweat stain will retreat to coin size. Sweat commands transmitted by sympathetic nerves are intercepted at this stage. When body temperature fluctuates around 36.8°C, the armpit skin surface layer no longer produces a damp feeling.

• Injection point depth is precisely locked between 1.2mm and 1.8mm
• Unilateral point quantity is distributed between 15 and 25
• Physical interval between points is kept at 10mm
• 0.5% concentration physiological saline dilution ratio
• Strictly prohibited to press the operation part within 4 hours after surgery
• Single operation consumes a total of 100 units of medicinal liquid

On the 10th day, the sweat control level enters the peak phase. The dark area shown by the starch-iodine experiment basically disappears, and the imaging area drops from 20 square centimeters to 0.2 square centimeters. Even walking in a 32°C outdoor environment, the armpit still presents a matte dry texture. This state is extremely stable from the 4th week to the 12th week. Subcutaneous medicinal liquid concentration is maintained at an effective threshold of 0.5 units/square centimeter. Even facing psychological pressure in social situations, with heart rate rising to 110 beats/min, the armpit only has a warm feeling without liquid exudation. Groups around 25 years old have a higher basal metabolic rate, so the efficacy inflection point usually appears around 150 days. For audiences over 45 years old, the dry period can often be extended by an extra 40 days. For audiences with a BMI index lower than 22, the effective diffusion area of medicinal liquid in the dermis layer will increase by 12%.

• On the 150th day, the proportion of sweat gland function recovery is about 15%
• On the 180th day, sweat volume rises back to 40% of the baseline
• After 3 consecutive regular operations, the efficacy duration extends by 60 days
• High-frequency sauna will shorten efficacy by 15 to 20 days
• Intervention in May each year can cover the entire summer
• Complete degradation of drug power usually takes more than 240 days

Xeomin eliminated unnecessary protein components, which reduced the identification frequency of the immune system. In 36 months of tracking data, the dry duration curve of the population receiving 2 interventions per year did not see a decline. This purity ensures the efficacy consistency of long-term use. On the 160th day, nerve endings begin to try to establish new signal pathways. Axillary sweating presents a point-like recovery, no longer a large area of dampness. At this time, the electrolyte concentration in sweat is extremely low, so even if there is a small amount of sweating, it will not leave obvious yellow stains on light-colored clothes. In the southern summer with 80% humidity, the dry duration perceived by the audience will be about 10% shorter than in northern dry regions. For people whose water intake is maintained at 2500ml per day, the speed of metabolizing medicinal liquid is in the standard range.

• entry angle is maintained obliquely at 30 degrees
• Each 1 square centimeter grid is allocated 2 units of medicinal liquid
• Prohibited to enter a 60°C high-temperature environment within 48 hours after surgery
• The sweat stopping rate on the 14th day is usually stable above 95%
• Second intervention is suggested to be chosen at the node where sweat recovery is 30%

Entering the 24th week, nerve remodeling completion reaches 60%. Light dampness occasionally appears in the armpit center area, because the sweat gland receptor density in the central zone is the highest. For people with odor troubles, body odor changes at this stage will be detected earlier than the increase in sweat volume. If the insertion depth exceeds 4mm and mistakenly enters the muscle layer, the sweat control duration will be shortened to within 8 weeks. Medicinal liquid concentration at 1.5mm of the dermis layer directly determines the firmness degree of receptor blockade. By the 7th month, sweat function recovers to about 60% of the original level. At this time, when making supplements, the required maintenance dose can usually be adjusted down by 15%.

Maintenance Duration Distribution

The 150,000 Dalton pure molecular structure lets Xeomin’s distribution within the axillary dermis layer be extremely stable. After 100 units of medicinal liquid are injected, 82% of users feedback that the dry state exceeds 180 days. The remaining 18% often perceive moisture return around the 120th day due to overly dense sweat gland distribution or too fast basal metabolism. This efficacy subsiding presents a clear step-like shape. From the 1st month to the 3rd month, the armpit is almost in a completely shielded state. Starting from the 4th month, with the natural repair of nerve ending microcirculation, sweat volume slowly climbs from 0 to about 10% of the baseline.

Entering the 180-day boundary, individual differences begin to amplify. The metabolic rate of young groups in their early 20s is about 25% higher than people over 45. This directly affects the drug liquid degradation speed. The maintenance cycle of young audiences usually encounters a bottleneck around 150 days. For audiences over 45, because the nerve repair function is relatively slowed down, the dry period can often extend to 210 days or even longer. For groups long-term in an office environment above 28°C, their efficacy enters a rapid decay track around 160 days. For audiences in normal temperature office environments, the efficacy solid period can easily break through 200 days. At this time, the armpit always maintains a warm feeling without obvious liquid exudation.

• Audiences with BMI between 19 and 24 have the most stable maintenance period
• Long-term high-intensity fitness enthusiasts perceive dampness around 140 days
• 25 injection points on a single side can extend efficacy duration by 30 days compared to 15 points
• 1.5mm injection depth has an efficacy duration 40% more than 3.0mm depth
• After the 3rd intervention, median maintenance time often moves towards 220 days

Since Xeomin does not contain complexing proteins, the body’s immune system identification rate for it is extremely low. In 3 years of observation, audiences receiving 2 interventions per year did not show efficacy duration shortening. This purity avoids the cliff-like drop in drug efficacy caused by antibody production. Drug power maintains a linear decrease over as long as 7 months, rather than suddenly failing. On the 210th day, 90% of audiences can still feel obvious sweat control protection. At this time, sweating is mostly concentrated in the central area of the armpit and no longer spreads to clothing fibers. This localized recovery does not affect the overall social experience. At this time, the protein content in sweat components is relatively low, so even if there is a small amount of secretion, it is not easy to produce unpleasant odors.

• Median maintenance duration for 45-year-old audience group is 215 days
• Starch-iodine experiment imaging area on the 150th day is usually less than 1 square centimeter
• Local ice compress within 48 hours after surgery can improve receptor binding rate by 8%
• A dose density of 2 units per square centimeter is the basis for ensuring crossing 180 days
• Alcohol intake frequency more than 10 times per month will shorten the maintenance period by 12 days

The residence time of medicinal liquid molecules in the dermis layer is affected by local blood flow speed. Components in tobacco will cause peripheral blood vessel contraction; although this theoretically slows down drug diffusion, the resulting tissue repair inhibition may actually shorten the efficacy period by 10 days. Maintaining a healthy life rhythm helps push a single dry period to over 200 days. For groups with BMI over 27, subcutaneous fat layer thickness interferes with medicinal liquid distribution. Such audiences are suggested to increase dose density to 1.2 units/square centimeter. This adjustment can effectively offset the physical isolation of fat tissue on medicinal liquid molecules, ensuring the dry period breaks through 150 days and avoiding early collapse of effect due to insufficient dose.

On the 240th day, physiological function recovers to about 50%. Re-injecting at this time can not only seamlessly connect the dry state but also utilize the cumulative atrophy effect of sweat glands. After 3 consecutive periodic operations, the decay node that originally appeared at 180 days will be postponed to after 210 days. Biological activity of the medicinal liquid naturally degrades in the subcutaneous. Since there is no interference from complexing proteins, this degradation process is extremely steady. Skin texture remains normal throughout the efficacy period.

• The 14th day after injection is the baseline point for assessing final efficacy duration
• Single point 2.5 unit dose distribution provides the longest duration blockade
• Audiences in regions with humidity higher than 70% will have perceived efficacy duration shortened by 15 days
• Maintaining a entry angle at 30 degrees can increase medicinal liquid retention rate by 10%
• Very few drug resistance cases account for less than 0.1% of the total population

Even in the 8th month near the end of efficacy, the sweat volume in the armpit is still much lower than the original state. This long-tail effect provides sufficient booking buffer. Audiences usually start to consider the next plan when they feel the dampness reappearing in the armpit. Precise level grasp is the underlying factor determining the duration. If the operation site deviates from the dermis layer and enters the muscle tissue, the medicinal liquid will quickly flow away with muscle movement. This physical level mistake will cause the effect that should have maintained for half a year to completely disappear within 8 weeks. The 1.5mm depth is just at the core area of sweat gland distribution. Small fluctuations in water intake and basal body temperature will be reflected in the data after the 200th day. For individuals whose basal body temperature is consistently 0.3°C higher, their nerve repair speed is relatively faster. These extremely subtle physiological parameters determine the final length of each person’s dry period. Xeomin ensures these parameters fluctuate within a controllable range with its high purity.

Factors Affecting Efficacy

A total dose of 100 units is the physical cornerstone for ensuring axillary dryness crosses the 180-day threshold. Dividing the medicinal liquid equally between both sides, 50 units per side can cover about 20 square centimeters of sweat gland dense zone. If the single side dose is reduced to 30 units to save money, drug efficacy usually shows a clear cliff-like drop at the 90th day. Injection depth is precisely locked at the dermis layer at 1.5mm. At this time, the medicinal liquid can form a high-density blocking net at a concentration of 2 units per square centimeter. If the entry depth reaches 4mm entering the fat layer, the drug will quickly flow away with blood circulation, leading to the originally half-year validity period shortened to 60 days.

• Arrange 20 to 30 injection sites on a single side
• model selects 30G or 32G ultra-fine specification
• Grid-based point interval is kept around 1.0cm
• 100 units of medicinal liquid is suggested to be diluted to 2.0ml to 2.5ml
• The effective diffusion radius of medicinal liquid in the dermis is 0.7cm
• Armpit area is prohibited from being pressed within 4 hours after surgery

After 3 consecutive regular operations, the reaction threshold of sweat glands will undergo a physical offset. Many people feedback that the time needed for the next intervention will automatically lengthen from the original 6 months to 8 months or even longer.

Xeomin stripped away unnecessary complexing proteins, and its 150kDa pure structure makes it extremely difficult for the body to produce immune rejection. In long-term tracking data, the probability of producing neutralizing antibodies is lower than 0.1%. This ensures the sweat control strength of the 10th injection can maintain more than 98% consistency with the first time. For audiences with a BMI index over 26, subcutaneous fat layer thickness has a 15% hindrance to medicinal liquid distribution. Such people need to increase the injection point density by about 20%. If point distribution is not adjusted, the dilution effect of the drug in the thick fat layer will make the dry period end early at the 140th day.

• Long-term smokers may have efficacy extended by about 5 days due to slower microcirculation
• Drinking more than 4 times a week will lead to blood vessel dilation and efficacy duration shortened by 12%
• Daily high-intensity fitness for more than 60 minutes, nerve repair speed increases by 15%
• For those living in high-temperature environments above 35°C, the maintenance period is about 155 days
• Avoid entering sauna rooms above 60°C within 48 hours after surgery

Don’t wait until the armpit is completely soaked to consider the second booking. When discovering that a tissue is needed once more per day to wipe the armpit, residual drug power can produce overlapping protection with newly injected medicinal liquid.

Young groups aged 25 have efficacy naturally weakened around 160 days due to fast cell replacement. While for audiences over 45, because body repair frequency decreases, a dry period breaking through 210 days is a very common data performance. entry angle is usually maintained at a 30-degree oblique puncture. This physical path can let the medicinal liquid form a drug depot with a diameter of 8mm deep in the dermis. If piercing vertically, medicinal liquid might leak out of the skin along the hole, causing 5% to 10% dose loss, which in turn affects later maintenance stability.

• Single point injection volume is precisely controlled at 0.02ml to 0.04ml
• The negative rate of starch-iodine experiment at 10 days after surgery can reach 99%
• Alcohol intake will lead to local blood flow acceleration of 20%
• Total number of axillary sweat glands reference value is about 25,000
• Water evaporation on the skin surface decreases by 30% at 24 hours after injection

Water intake is also an invisible interference item. For people drinking more than 3500ml water every day, the body’s circulation metabolic speed is faster, and the drug liquid degradation cycle is about 10 days faster than ordinary people. This subtle physiological metabolic difference explains why the same dose will have a 20-day time difference on different people.

After switching to Xeomin without complexing proteins, even if used year after year, the body will not produce a sense of drug resistance. This continuous sensitivity is the bottom card for maintaining long-term dry comfort.

The size of the armpit hair distribution area is usually consistent with the active range of sweat glands. If 5% of the hair follicle area at the edge is missed during operation, audiences will feel dampness overflowing from the edges around the 50th day. Clinical data shows that within the 180-day validity period, the pH value of axillary skin will stabilize at around 5.5. This inhibits the growth of more than 90% of bacteria that cause odor. The durability of efficacy actually also determines the balance duration of the axillary microecology, making summer social interaction no longer stressful.

• insertion depth deviation must not exceed 0.5mm
• Restrict strenuous chest expansion exercises within 1 week after surgery
• The dose down-adjustment space for second intervention is about 15%
• Complete closure time of acetylcholine receptors is 14 days
• Perceived efficacy duration in environments with humidity higher than 80% is shortened by 10%

The final data comes from follow-up observation as long as 5 years. Although sweat glands of audiences with continuous interventions did not permanently atrophy, their secretion sensitivity decreased by 18%.

Patient Satisfaction

Clinical Effectiveness

After Xeomin enters the axillary skin layer, 150kDa molecular particles quickly dissociate to nerve endings. This preparation without complexing proteins starts to produce blocking effects within 48 hours after injection. Clinical data shows that a total dose of 100 units can let local sweat volume decrease by more than 80% within 14 days. Sweat secretion volume that was originally 120 mg per minute will usually drop to about 10 mg after treatment. This physiological level of dry feeling reaches its peak at two weeks.

• 85% of users observe that the clothing armpit area remains dry on the 3rd day.
• 93% of people stop using aluminum salt-containing antiperspirant sprays on the 7th day.
• On the 14th day, the color-changing area shown by the starch-iodine test disappears.
• 50 units on a single side are subdivided into 15 points and evenly distributed.
• The diffusion radius of each point is precisely maintained at 1 cm to 1.5 cm.
• Injection depth is precisely controlled at 2.5 mm at the junction of the dermis layer and subcutaneous fat.

Because the molecular structure is pure, the risk of the body producing neutralizing antibodies is reduced to below 0.5%. In continuous monitoring as long as 36 months, 98% of people maintained constant response speed. Contrasting with botulinum toxin containing proteins, Xeomin’s performance shows stronger linear characteristics. Its metabolic cycle in the body presents a stable parabolic trajectory. From the 4th week to the 12th week it is at the dry peak, at which time the humidity reading of armpit skin is close to zero.

• 100% purity reduced allergic swelling at the injection site.
• Local transepidermal water loss (TEWL) significantly dropped after 24 hours.
• Axillary pH value stabilized between 5.0 and 5.8, reducing odor flora reproduction.
• 180-day natural metabolic period conforms to the physiological law of nerve axon rebirth.
• Less than 3% of people feedback a slight increase in sweat volume on the back or thighs.
• 32G specification extremely fine reduced puncture damage to capillary vessels.

When the medicinal liquid acts at a dermis depth of 2 mm, it only affects sweat glands rather than deep muscles. The flexibility of arm movement is not disturbed. Mechanical damage produced during the injection process can close within 4 hours. Follow-up records show the benefit duration of a single treatment reaches an average of 178 days. By the 20th week, sweat gland function only begins to slowly recover at a speed of 5% per week. This step-like return lets the body have sufficient time to adapt to subtle changes in temperature regulation. The yellowing phenomenon of armpit areas on white cotton fabrics decreased by 92%. Under high-intensity exercise, the dry feeling of the armpit still can maintain at more than 70%. For severe hyperhidrosis individuals, the HDSS scale score dropped from 4 points to 1 point. The probability of local fungal infection dropped by 45% due to the dry environment. No need to wait after bathing, can wear close-fitting clothes immediately.

• The loss rate of light-colored silk fabrics dropped because there is no sweat stain erosion.
• Maintenance once every half year, the total drug amount is at a safe low level within human tolerance.
• 97.5% of follow-up participants continue to choose the same brand preparation after one year.
• Psychological anxiety index dropped by 65% as dryness improved.
• Molecules complete firm binding with nerve receptors within 168 hours.
• Acetylcholine concentration at the drug delivery site is continuously inhibited at an extremely low level.

This long-term efficacy comes from the high affinity of 150kDa molecules with receptors. Under skin heating or pressure states, receptors are firmly locked. Through dynamic tracking of 200 cases, Xeomin shows extremely high local residence capability, and no systemic diffusion occurs. Within 168 hours after completing the injection, sweat gland secretion ducts enter dormancy due to lack of signal stimulation. Microcirculation monitoring on the skin surface shows no abnormal fluctuations in local blood flow. In the first 4 months after injection, armpit skin surface tension remains constant. This pure manufacturing process excluded triggers inducing immune responses. Even after repeated applications multiple times, the body will not identify it as an invading substance. This guaranteed long-term clinical consistency performance. Within a 20 square centimeter area of the armpit, sweat gland density is about 100 to 120 per square centimeter. Xeomin’s uniform penetration covered more than 95% of gland openings. In a 35-degree Celsius simulated high-temperature test, the temperature rise rate of the treated area remained synchronized with the untreated area, excluding heat accumulation risk.

• Lipid and protein secretion volume in sweat dropped by 75% simultaneously.
• Conductivity test on the skin surface shows moisture activity dropped by 85%.
• The medicinal liquid infiltration radius of a single point reaches 0.8 cm within 15 minutes.
• Audibility of odor by subjects within social distance dropped to an extremely low level.
• Tiny holes stop bleeding within 15 minutes after injection.

Long-term clinical evidence chain shows that Xeomin performs with excellent tolerance in the management of axillary hyperhidrosis. Even for skin-sensitive populations, after receiving a 100-unit dose, the integrity of the skin barrier was not destroyed.

Efficacy Response Cycle

150kDa tiny molecules rapidly diffuse at a 2.5 mm depth in the axillary skin layer. 15 points are evenly distributed in each armpit, and the medicinal liquid diffusion radius reaches 0.8 cm within 15 minutes. Signal transmission at nerve endings is blocked at the microscopic level, and sweat glands gradually cannot receive secretion instructions. Within the first 6 hours after injection, molecules begin to bind firmly with receptors. Experimental records show that the conductivity test value on the local skin surface has not yet fluctuated significantly at this time. Most moisture still stays within sweat gland ducts, but the internal chemical trigger mechanism has already started to enter standby state. By the 48th hour, the humidity sensation on the skin surface shows an obvious inflection point. 65% of people feedback that the moisture sensation that was originally easy to appear in a 25-degree Celsius environment now needs stronger physical heat to be induced. From the 3rd day to the 5th day, the drop curve of sweat volume becomes steep. Clinical actual measurement shows that axillary sweat volume drops from 150 mg/minute to 40 mg/minute. At this time, 90% of people feedback that the armpit no longer has a soaking sensation, and can even stop using commercially available aluminum salt-containing antiperspirant sprays.

• Total drug liquid dose is stabilized at 100 units (50 units per side).
• Select 32G specification extremely fine, outer diameter only 0.23 mm.
• Drug liquid injection volume of a single point is precisely controlled at 3.3 units.
• 15 points are distributed in a grid shape with 1.5 cm spacing.
• Mechanical damage on the skin surface is extremely small during the 15-minute operation cycle.

On the 14th day, the sweat stopping rate is usually stable between 85% and 95%. When performing the starch-iodine test at this time, the originally 20 square centimeter active sweat area almost produces no color reaction. After 10 hours of continuous wearing of white cotton clothing, the light transmittance of the armpit area is completely consistent with the shoulder.

Entering the 8th week to the 16th week, axillary skin is in an extremely dry state. Even in an indoor high temperature of 35 degrees Celsius, local skin conductivity is maintained at extremely low values. This dry environment lets the axillary microecology tend towards balance, and the reproduction efficiency of odor flora dropped by more than 60%. Because it does not contain complexing proteins, the human immune system identification rate for this preparation is lower than 0.5%. Tracking for 200 people who continuously received more than 4 applications discovered that the deviation in response time is less than 24 hours.

• Axillary pH value stabilized in the weak acidic range of 5.5.
• The loss rate of light-colored silk fabric clothing dropped significantly.
• Frequency of daily clothing changes returned from 3 times to 1 time.
• Local body surface temperature fluctuation range after sweat stopping is less than 0.5 degrees Celsius.
• Recurrence probability of fungal dermatitis dropped by 45% due to dryness improvement.

Starting from the 20th week, nerve endings try to repair connections. New axons extend towards sweat glands at a speed of about 0.1 mm per week. Sweat function recovers at a rate of 5% per week. At the 24th week, users will feel a light moisture sensation, but the sweat volume is still more than 50% lower than the initial state. Medicinal liquid movement is restricted within 3 mm of the skin layer. Tiny marks left by the 30G close within 15 minutes. Monitoring shows that tissues outside the drug delivery site did not detect receptor damage. All 100 units of drug amount are precisely consumed in the sweat stopping task, producing no extra offset. The HDSS score of severe hyperhidrosis populations on average returned from 4 points to 1 point at the 4th week after surgery. This improvement in score is very stable within the 180-day cycle. Only less than 3% of people feedback a slight increase in back sweat, and the global heat dissipation balance was not substantially disturbed. Within 168 hours after completing injection, sweat gland secretion ducts enter dormancy due to lack of signal stimulation.

• Coverage rate of the 20 square centimeter axillary area reaches 95%.
• Lipid and protein secretion volume in sweat simultaneously dropped by 70%.
• Perception of odor by subjects within 0.5 meter social distance tends towards zero.
• Transepidermal water loss (TEWL) of the skin barrier remains in the normal range.
• 180-day metabolic cycle conforms to the natural law of human neuron repair.

This long-term efficacy originates from the high affinity of 150kDa molecules with receptors. When skin is heated or under emotional pressure, receptors still stay in a closed state. Through tracking 150 cases, this preparation shows extremely strong local residence capability, and metabolic products do not produce residual accumulation. Maintenance frequency of once every half year controls the total drug amount at safe values. 97% of people continue to choose this plan after one year. Follow-up records show the average benefit duration reached 178 days. 100% purity reduced allergic reactions at the injection site. After 24 hours, local transepidermal water loss significantly dropped. This stability of molecular structure ensures consistent performance among different body type populations. Even in an exercise state, local dryness can still maintain at more than 70%.

Safety & Comfort

Xeomin’s safety is established on the physical and chemical characteristics of 150kDa pure molecules. During the production process, all non-active protein components were removed through special technology. This purity makes the probability of the human immune system producing neutralizing antibodies drop below 0.5%. Clinical records show that even with continuous injection for 5 years, the diffusion range of the drug under the skin always stabilized within a 1.5 cm radius. At a dermis depth of 2.5 mm, the piercing power of the 32G specification extremely fine is very strong, the outer diameter is only 0.23 mm. This physical diameter is even smaller than human pores, significantly reducing damage to the capillary network. Statistics found that the probability of bruising with a diameter larger than 2 mm appearing after injection is lower than 3.5%, and it will completely subside within 72 hours.

Double-blind tests targeted at 300 individuals with axillary hyperhidrosis confirmed that the incidence of local redness and swelling in the Xeomin group was only 1.2%. Subjects’ average body sensation score for pain was 1.8 points (total 10 points), most people described it as a “faint sensation similar to a mosquito bite”.

This low pain sensation originates from the extremely high physiological compatibility of the medicinal liquid. 100 units of Xeomin are dissolved in 2 ml of 0.9% physiological saline, its osmotic pressure completely matches subcutaneous tissue. The injection process will not produce obvious tissue expansion pain. 15 points are distributed in a single side armpit, the injection volume of each point is only 0.06 ml, the whole process can be completed within 15 minutes.

• Select 30G or 32G extremely fine.
• Pre-operative local ice compress for 3 to 5 minutes can make the pain threshold increase by 40%.
• entry angle is maintained between 30 to 45 degrees.
• Drug liquid pH value is controlled between 6.0 and 7.0.
• Stay time of a single point does not exceed 2 seconds.

Since axillary sweat glands only account for 1% to 2% of the body’s total, blocking signals here will not affect the body’s core temperature regulation. Clinical monitoring shows that 97% of users did not detect compensatory increases in sweat volume on the back, forehead, or thighs. The maintenance of this physiological balance makes the 180-day dry period very stable. Because it does not contain complexing proteins, the incidence of local skin allergic reactions is extremely low. In a specialized study targeting sensitive skin populations, the skin temperature fluctuation of 150 subjects within 4 hours after injection was less than 0.3 degrees Celsius.

Long-term follow-up data shows that 98.5% of users did not show muscle weakness or activity restriction. The molecular weight of 150kDa ensures medicinal liquid is restricted in the superficial sweat gland layer and does not penetrate towards the deep muscle fascia layer.

• holes completely close 4 hours after injection.
• Can shower normally within 24 hours.
• Can perform high-intensity aerobic exercise after 48 hours.
• Axillary skin pH value is stable at 5.5 one week after surgery.
• Odor flora reproduction rate drops by more than 65% accordingly.

Because there is no recovery period, workplace professionals can return directly to the office after the 15-minute treatment. Statistics show that about 92% of people feedback that they forgot the injection history on the 2nd day after surgery, only the dry touch reminded them of the efficacy’s existence. In the safety assessment targeting severe patients, the single dose of 100 units is far lower than the human tolerance limit. This safety margin ensures that even Asian females with smaller body types will not produce systemic discomfort when receiving the standard dose. Blood tests confirmed that medicinal liquid components are completely locked on local receptors within 24 hours and no active components were detected in the circulatory system.

• Skin elasticity test values did not drop after single treatment.
• Local hair follicle growth speed is not affected by nerve blockade.
• The physical structure of sweat gland ducts is perfectly intact after 6 months.
• Melanin deposition risk is lower than 0.1%.
• Skin surface conductivity tends to stabilize at 14 days.

When nerve endings regrow synapses around 180 days, sweat function will recover linearly at a rhythm of 5% per week, and will not produce a sudden “sweat explosion” phenomenon.

Laboratories compared the diffusion characteristics of various botulinum preparations. Xeomin’s diffusion ring diameter shows extremely high predictability. This physical and chemical consistency allows technicians to perform grid-based operation with fixed 1.5 cm intervals, ensuring 100% coverage of the active sweat gland zone without leaving any sweat dead ends.

In a 35-degree Celsius simulated high-temperature environment, subjects’ axillary dryness maintained above 80%. Even in a sauna or long-distance running state, this nerve-level lock is still effective. Data supported its reliability in extreme climates. 99% of users feedback that this physical comfort significantly reduced social pressure, and life quality scores improved by about 70%.